We know that some people who take PrEP have short-term side effects such as nausea when first starting to take the medication. These side effects usually stop within a few weeks.

Decreased kidney function is a possible side effect. Changes to kidney function have been reversed when people stop taking the medication. Decreased bone density is also a possible side effect of Truvada, but more research is needed to understand this side effect for those of us who are HIV-negative. Decreased bone density is also a possible side effect, and it has also been reversed when people stop taking Truvada. More research is needed to understand this side effect for those of us who are HIV-negative.

These possible side effects are one reason why those of us taking PrEP need to see a health care provider regularly; in most cases, appointments are needed every three months.